SYNTHESIS AND CHARACTERIZATION OF ALOEVERA-CURCUMIN LOADED ZEIN NANO FIBROUS SMART DRESSING FOR DIABETIC FOOT ULCER

Authors

  • Nisha Iqbal Department of Bio-Medical Engineering, University of Naples Federico II, Italy
  • Haris Tejani Mehran University of Engineering and Technology Jamshoro, Sindh, Pakistan.
  • Aisha Siddiqa Mehran University of Engineering and Technology Jamshoro, Sindh, Pakistan.
  • Heer Memon Mehran University of Engineering and Technology Jamshoro, Sindh, Pakistan.
  • Abdul Qadir Ansari Mehran University of Engineering and Technology Jamshoro, Sindh, Pakistan.
  • Rabia Almas Mehran University of Engineering and Technology Jamshoro, Sindh, Pakistan.

DOI:

https://doi.org/10.56220/uwjst.v9i.238

Keywords:

Keywords—Diabetic foot ulcers, DFU, Nanofibers and scaffold

Abstract

Diabetes is one of the predominant healthcare problems that affects the globe with high fatality and comorbidity rates and its associated complications involving diabetic foot ulcers (DFU). According to the various clinical reports, a major contributing factor to the challenges in healing the DFU is the infection, changes in the inflammatory responses, a deficiency in the extracellular matrix, and a failure of angiogenesis. Nanofibers that replicate natural materials exhibit significant porosity, excellent moisture absorption, and a greater oxygen exchange rate. These properties are highly desirable for DFU treatment. In this research, we synthesized a nanofibrous scaffold containing curcumin and aloe vera, two natural therapeutic elements, encapsulated in a biodegradable polymer named Zein. The morphology of the nanofibrous scaffold was examined, confirming that the fibers were perfectly sized and had a smooth, bead-free structure. Additionally, the presence of chemical components (C-O, C=C and S=O, and C=N groups of Cr and Av with Zein polymer) was evaluated, and the drug release profile was found to be efficient along with excellent antibacterial performance. All these outcomes were received using the SEM, FTIR, and UV-VIS characterization methods, respectively.

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Published

2025-12-25

How to Cite

Iqbal, N., Tejani, H., Siddiqa, A., Memon, H., Ansari, A. Q., & Almas , R. (2025). SYNTHESIS AND CHARACTERIZATION OF ALOEVERA-CURCUMIN LOADED ZEIN NANO FIBROUS SMART DRESSING FOR DIABETIC FOOT ULCER. University of Wah Journal of Science and Technology (UWJST), 9, 46–54. https://doi.org/10.56220/uwjst.v9i.238

Issue

Vol. 9 (2025): University of Wah Journal of Science and Technology

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Articles

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Copyright (c) 2025 Nisha Iqbal, Haris Tejani, Aisha Siddiqa, Heer Memon, Abdul Qadir Ansari, Rabia Almas

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